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Search Results for " cyclin A "

ターゲット

CDK

167

阻害剤

天然化合物

183

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T5673	Senexin A		CDK
	Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.		CDK
T2029	Bohemine		ERK , CDK
	Bohemine is a cyclin-dependent kinase inhibitor.		ERK , CDK
T7426	ALSTERPAULLONE		Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec		Apoptosis , GSK-3 , CDK
T2059	Purvalanol A	NG-60	Apoptosis , CDK , Autophagy
	Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.		Apoptosis , CDK , Autophagy
T22260	Aminopurvalanol A		CDK
	Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 n...		CDK
T11929	M2N12		Phosphatase
	M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhi...		Phosphatase
T14778	BRD6989		IL Receptor , CDK , Interleukin
	BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex...		IL Receptor , CDK , Interleukin
T9078	LY3405105	1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester	CDK
	LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) is a novel CDK7 inhibitors.		CDK
T7698	BS194		CDK
	BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.		CDK
T15335	FN-1501		FLT , CDK
	FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.		FLT , CDK
T2378	RGB-286638 free base		GSK-3 , MEK , JAK , CDK
	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a...		GSK-3 , MEK , JAK , CDK
T39957	CDK4/6-IN-6		CDK
	CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.		CDK
T2095	Seliciclib	Roscovitine,R-roscovitine,CYC202	CDK
	Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM).		CDK
T8796	CAN508		CDK
	CAN508 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 and 20 μM, respectively.CAN50...		CDK
T14916	CDK2-IN-4		CDK
	CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.		CDK
T61477	DCeMM2		Molecular Glues
	dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.		Molecular Glues
T14914	Cdk1/2 Inhibitor III		CDK
	Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.		CDK
T9758	DCeMM3	2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide	Others
	dCeMM3 (2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide) is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradati...		Others
T7167	Purvalanol B	NG 95	CDK , Parasite
	Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)		CDK , Parasite
T5200	Indirubin-3'-monoxime	Indirubin-3'-oxime	GSK-3 , Lipoxygenase , CDK
	Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).		GSK-3 , Lipoxygenase , CDK
T34888	TL12-186	TL12 186,TL12186	CDK , Ligand for E3 Ligase
	TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.		CDK , Ligand for E3 Ligase
T60485	DIF-3
	DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signal...
T6787	BIO-acetoxime	BIA,GSK-3 Inhibitor X	Apoptosis , GSK-3 , HSV
	BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.		Apoptosis , GSK-3 , HSV
T2615	Flavopiridol hydrochloride	Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl	HIV Protease , CDK , Autophagy
	Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of ...		HIV Protease , CDK , Autophagy
T21720	GP-82996	Cdk4/6 Inhibitor IV,CINK4	CDK
	GP-82996 (CINK4) is a pharmacological inhibitor specifically targeting CDK4/6, exhibiting IC50 values of 1.5 μM for CDK4/cyclin D1, 5.6 μM for CDK6/cyclin D1, and 25 μM for Cdk5/p35. It effectively induces apoptosis in U...		CDK
T3207	Briciclib	ON 014185	CDK , PERK , Autophagy
	Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.		CDK , PERK , Autophagy
T9849	HQ461		CDK , Molecular Glues
	HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.		CDK , Molecular Glues
T39403	Avotaciclib	BEY1107,Avotaciclib	CDK
	Avotaciclib (BEY1107) is a potent and orally active cyclin dependent kinase 1 (CDK1) inhibitor.Avotaciclib can be used to study locally advanced or metastatic pancreatic cancer.		CDK
T21314	Amsilarotene	TAC-101,TAC 101,TAC101	CDK
	Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy...		CDK
T6358	1-Azakenpaullone	azakenpaullone	GSK-3
	1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.		GSK-3
T2679	BMS-265246	BMS265246	CDK
	BMS-265246 is a potent and selective CDK1/2 inhibitor.		CDK
T11826	LCH-7749944	GNF-PF-2356	Apoptosis , PAK
	LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor w...		Apoptosis , PAK
T21588	Olomoucine		ERK , CDK
	Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits an...		ERK , CDK
T14943	CGP60474		VEGFR , CDK , PKC
	CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently.		VEGFR , CDK , PKC
T5169	SGC-GAK-1		Serine/threonin kinase
	SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).		Serine/threonin kinase
T8535	GAK inhibitor 49		Serine/threonin kinase
	GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ).		Serine/threonin kinase
T16359	NU6140		CDK , Aurora Kinase
	NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e...		CDK , Aurora Kinase
T16391	ON-013100		CDK
	ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.		CDK
T10745	CDK9-IN-7		CDK
	CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM).		CDK
T2247	KenPaullone	9-Bromopaullone,NSC-664704	GSK-3 , CDK
	KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through increased and prolonged transcription of foxp...		GSK-3 , CDK
T6312	R547	Ro 4584820	Apoptosis , GSK-3 , PKA , CDK
	R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.		Apoptosis , GSK-3 , PKA , CDK
T9446	KB-0742 dihydrochloride		CDK
	KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.		CDK
T2356	Ro-3306		Apoptosis , ERK , SGK , PKA , CDK , PKC
	RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.		Apoptosis , ERK , SGK , PKA , CDK , PKC
T15732	Ribociclib succinate	LEE011 succinate	CDK
	Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B/CDK1 complex.		CDK
T8972	FIT-039		Others , DNA/RNA Synthesis , CDK , HSV
	FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr...		Others , DNA/RNA Synthesis , CDK , HSV
T23840	BUR1	BMP upregulator-1,BMP upregulator 1,BUR 1,BUR-1	CDK
	BUR1 is a selective BMP upregulator that acts by increasing the expression of Inhibitor of DNA binding 1 and inducing BMP2 and PTGS2 expression.		CDK
T3465	Vesnarinone	OPC-8212,Arkin,Piteranometozine	HIV Protease , PDE
	Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel...		HIV Protease , PDE
T8463	PF-06873600		CDK
	PF-06873600 is a selective and orally bioavailable cyclin-dependent kinase (CDK) inhibitor(CDK2, CDK4 and CDK6 with Ki of 0.09 nM, 0.13 nM and 0.16 nM, respectively), has potential antineoplastic activity.		CDK
T4321	Indisulam	E 7070	CDK , Carbonic Anhydrase
	Indisulam (E 7070) is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in th...		CDK , Carbonic Anhydrase
T10572	BMT-124110		AAK1 (AP2 associated kinase 1)
	BMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM. BMT-090605 inhibits cyclin G-associated kinase GAK with an...		AAK1 (AP2 associated kinase 1)

Compounds

Target: Apoptosis, GSK-3, CDK

Purvalanol A

T2059

Synonym: NG-60

Target: Apoptosis, CDK, Autophagy

Target: IL Receptor, CDK, Interleukin

LY3405105

T9078

Synonym: 1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester

Target: GSK-3, MEK, JAK, CDK

Synonym: Roscovitine,R-roscovitine,CYC202

Target: Molecular Glues

Synonym: 2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide

Target: CDK, Parasite

Indirubin-3'-monoxime

T5200

Synonym: Indirubin-3'-oxime

Target: GSK-3, Lipoxygenase, CDK

TL12-186

T34888

Synonym: TL12 186,TL12186

Target: CDK, Ligand for E3 Ligase

Synonym: BIA,GSK-3 Inhibitor X

Target: Apoptosis, GSK-3, HSV

Flavopiridol hydrochloride

T2615

Synonym: Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl

Target: HIV Protease, CDK, Autophagy

GP-82996

T21720

Synonym: Cdk4/6 Inhibitor IV,CINK4

Target: CDK, PERK, Autophagy

HQ461

T9849

Synonym:

Target: CDK, Molecular Glues

Avotaciclib

T39403

Synonym: BEY1107,Avotaciclib

Target: CDK

Amsilarotene

T21314

Synonym: TAC-101,TAC 101,TAC101

Target: CDK

1-Azakenpaullone

T6358

Synonym: azakenpaullone

Target: Apoptosis, PAK

Target: VEGFR, CDK, PKC

SGC-GAK-1

T5169

Synonym:

Target: Serine/threonin kinase

GAK inhibitor 49

T8535

Synonym:

Target: Serine/threonin kinase

NU6140

T16359

Synonym:

Target: CDK, Aurora Kinase

Synonym: 9-Bromopaullone,NSC-664704

Target: Apoptosis, GSK-3, PKA, CDK

KB-0742 dihydrochloride

Target: Apoptosis, ERK, SGK, PKA, CDK, PKC

Ribociclib succinate

T15732

Synonym: LEE011 succinate

Target: Others, DNA/RNA Synthesis, CDK, HSV

BUR1

T23840

Synonym: BMP upregulator-1,BMP upregulator 1,BUR 1,BUR-1

Target: CDK

Vesnarinone

T3465

Synonym: OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Target: CDK, Carbonic Anhydrase

BMT-124110

T10572

Synonym:

Target: AAK1 (AP2 associated kinase 1)

カタログ番号	製品名	別名	ターゲット
T6169	Indirubin	Indigopurpurin,Indigo red,NSC 105327,Couroupitine B	Apoptosis , Raf , GSK-3 , CDK
	Indirubin (Couroupitine B) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.		Apoptosis , Raf , GSK-3 , CDK
TN1637	Eurycomalactone		Anti-infection , NF-κB
	Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in...		Anti-infection , NF-κB
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R
T5S1467	Cucurbitacin E		CDK , Autophagy
	Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot...		CDK , Autophagy
T6S0221	Eriocitrin	eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside	Apoptosis , Carbonic Anhydrase
	1. Eriocitrin (Eriodictyol-7-O-Rutinoside) is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in a rat model of high-fat diet....		Apoptosis , Carbonic Anhydrase
T3S0737	Flavokawain A	Flavokavain A	Apoptosis , p38 MAPK
	NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant...		Apoptosis , p38 MAPK
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T27305	Fascaplysin chloride	NSC622398,NSC 622398,Fascaplysin,NSC-622398
	Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human ...
TN6198	Mahanine
	Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can r...

天然物製品

Indirubin

T6169

Synonym: Indigopurpurin,Indigo red,NSC 105327,Couroupitine B

Target: Apoptosis, Raf, GSK-3, CDK

Eurycomalactone

TN1637

Synonym:

Target: Anti-infection, NF-κB

Ginsenoside Rg5

T6S1487

Synonym:

Target: NF-κB, COX, IGF-1R

Cucurbitacin E

T5S1467

Synonym:

Target: CDK, Autophagy

Eriocitrin

T6S0221

Synonym: eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside

Target: Apoptosis, Carbonic Anhydrase

Flavokawain A

T3S0737

Synonym: Flavokavain A

Target: Apoptosis, p38 MAPK

Schisandrol B

T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Jaceosidin

T3824

Synonym:

Target: Apoptosis, BCL, COX, UGT

Fascaplysin chloride

T27305

Synonym: NSC622398,NSC 622398,Fascaplysin,NSC-622398

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04548	CDK4 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cel...
TMPY-00978	Progranulin Protein, Human, Recombinant (His)	Human	HEK293
	Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ...
TMPY-01401	Cyclin A1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of...
TMPY-03535	Cyclin E Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that...
TMPJ-00972	CDKN1B Protein, Human, Recombinant (His)	Human	E. coli
	Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skele...
TMPY-02777	Cyclin E Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that...
TMPY-01550	Cyclin E Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that...
TMPJ-00936	CCND2 Protein, Human, Recombinant (His)	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each ...
TMPY-04542	CDK2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas...
TMPH-01359	CCND1 Protein, Human, Recombinant (His)	Human	E. coli
	Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylat...
TMPY-02495	P19 INK4d Protein, Human, Recombinant (GST)	Human	E. coli
	Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S tran...
TMPJ-00963	CDKN2C Protein, Human, Recombinant (His)	Human	E. coli
	Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in...
TMPY-03599	RPRD1B Protein, Human, Recombinant (His)	Human	HEK293
	RPRD1B, together with RPRD1A, can accompany RNAP II from promoter regions to 3'-untranslated regions during transcription in vivo, predominantly interact with phosphorylated RNAP II, and can reduce CTD S5- and S7-phospho...
TMPK-00016	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell prolifer...
TMPK-00015	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell prolifer...
TMPY-04775	CDK1 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote...
TMPY-04463	CDKL2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus...
TMPH-02471	14-3-3 beta/alpha Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine moti...
TMPY-04549	CDK1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	CDC2, also known as CDK1, contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. CDC2 is a catalytic subunit of the highly conserved prote...
TMPY-04556	CDK5 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which...
TMPH-02472	14-3-3 beta/alpha Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine moti...
TMPY-03411	ENSA Protein, Human, Recombinant (His)	Human	E. coli
	Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle ...
TMPY-02114	PIN1 Protein, Human, Recombinant	Human	E. coli
	Peptidyl-prolyl cis-trans isomerase Pin1, also known as Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Rotamase Pin1 and PIN1, peptidyl-prolyl cis/trans isomerase (PPIase), is a nucleus protein. PIN1 is a peptid...
TMPY-02076	PIN1 Protein, Human, Recombinant (His)	Human	E. coli
	Peptidyl-prolyl cis-trans isomerase Pin1, also known as Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Rotamase Pin1 and PIN1, peptidyl-prolyl cis/trans isomerase (PPIase), is a nucleus protein. PIN1 is a peptid...
TMPY-05654	ENSA Protein, Human, Recombinant (His), Biotinylated	Human	E. coli
	Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle ...
TMPY-02921	CDK2AP2 Protein, Human, Recombinant (His)	Human	E. coli
	CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including...
TMPH-01831	Human Papilloma Virus type 16 (HPV 16) Protein E4 (His & Myc)	HPV 16	E. coli
	Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPJ-01097	ZBTB17 Protein, Human, Recombinant (His)	Human	E. coli
	Zinc Finger and BTB Domain-Containing Protein 17 (ZBTB17) belongs to the Kruppel C2H2-type zinc finger protein family. ZBTB17 may function as a housekeeping DNA-binding protein that regulates the expression of specific g...
TMPH-01826	Human Papilloma Virus type 11 (HPV 11) Protein E4 (His)	HPV 11	E. coli
	Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPH-01839	Human Papilloma Virus type 6a (HPV 6a) Protein E4 (His & Myc)	HPV 6a	E. coli
	Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPY-04023	BCCIP Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ...
TMPY-00578	BCCIP Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ...
TMPY-02766	PSPH Protein, Human, Recombinant	Human	E. coli
	Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a ro...
TMPH-01329	FBXW7 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds pho...
TMPH-03264	P53 Protein, Rat, Recombinant (His)	Rat	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-02574	P53 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPY-01435	Progranulin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ...
TMPY-00150	IGF2/IGF-II Protein, Human, Recombinant	Human	Yeast
	Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele,...
TMPH-01075	P53 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-03281	PRKN Protein, Rat, Recombinant (His & Myc)	Rat	Baculovirus
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-01262	PRKN Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-01263	PRKN Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-02631	PRKN Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPK-01422	Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi)	Human	HEK293
	Peptide Ready HLA-A02:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,...
TMPK-01421	Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293
	HLA-A02:01&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,...
TMPK-01415	APC-equivalent Peptide Ready HLA-A*02:01&B2M Tetramer Protein, Human, MHC (His)	Human	HEK293
	Peptide Ready HLA-A02:01&B2M Tetramer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A02:01. Peptide ready MHC molecules comprising human HLA alleles and B2M...
TMPK-01420	Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi)	Human	HEK293
	Peptide Ready HLA-A03:01&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-A03:01. Peptide ready MHC molecules comprising human HLA alleles and B2M,...
TMPK-01410	Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi)	Human	HEK293
	Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can b...
TMPK-01554	HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, en...
TMPK-01519	HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293
	Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple ...
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CDK4 Protein, Human, Recombinant (GST)

TMPY-04548

Species: Human

Expression System: Baculovirus-Insect Cells

Progranulin Protein, Human, Recombinant (His)

TMPY-00978

Species: Human

Expression System: HEK293

Cyclin A1 Protein, Human, Recombinant (His)

TMPY-01401

Species: Human

Expression System: Baculovirus-Insect Cells

Cyclin E Protein, Mouse, Recombinant (His & GST)

TMPY-03535

Species: Mouse

Expression System: Baculovirus-Insect Cells

CDKN1B Protein, Human, Recombinant (His)

TMPJ-00972

Species: Human

Expression System: E. coli

Cyclin E Protein, Human, Recombinant (His & GST)

TMPY-02777

Species: Human

Expression System: Baculovirus-Insect Cells

Cyclin E Protein, Human, Recombinant (His)

TMPY-01550

Species: Human

Expression System: Baculovirus-Insect Cells

CCND2 Protein, Human, Recombinant (His)

TMPJ-00936

Species: Human

Expression System: E. coli

CDK2 Protein, Human, Recombinant (His)

TMPY-04542

Species: Human

Expression System: Baculovirus-Insect Cells

CCND1 Protein, Human, Recombinant (His)

TMPH-01359

Species: Human

Expression System: E. coli

p19 INK4d Protein, Human, Recombinant (GST)

TMPY-02495

Species: Human

Expression System: E. coli

CDKN2C Protein, Human, Recombinant (His)

TMPJ-00963

Species: Human

Expression System: E. coli

RPRD1B Protein, Human, Recombinant (His)

TMPY-03599

Species: Human

Expression System: HEK293

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated

TMPK-00016

Species: Human,Mouse,Goat

Expression System: E. coli

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)

TMPK-00015

Species: Human,Mouse,Goat

Expression System: E. coli

CDK1 Protein, Mouse, Recombinant (His & GST)

TMPY-04775

Species: Mouse

Expression System: Baculovirus-Insect Cells

CDKL2 Protein, Human, Recombinant (His)

TMPY-04463

Species: Human

Expression System: Baculovirus-Insect Cells

14-3-3 beta/alpha Protein, Mouse, Recombinant (E. coli, His)

TMPH-02471

Species: Mouse

Expression System: E. coli

CDK1 Protein, Human, Recombinant (GST)

TMPY-04549

Species: Human

Expression System: Baculovirus-Insect Cells

CDK5 Protein, Human, Recombinant (GST)

TMPY-04556

Species: Human

Expression System: Baculovirus-Insect Cells

14-3-3 beta/alpha Protein, Mouse, Recombinant (His)

TMPH-02472

Species: Mouse

Expression System: Yeast

ENSA Protein, Human, Recombinant (His)

TMPY-03411

Species: Human

Expression System: E. coli

PIN1 Protein, Human, Recombinant

TMPY-02114

Species: Human

Expression System: E. coli

PIN1 Protein, Human, Recombinant (His)

TMPY-02076

Species: Human

Expression System: E. coli

ENSA Protein, Human, Recombinant (His), Biotinylated

TMPY-05654

Species: Human

Expression System: E. coli

CDK2AP2 Protein, Human, Recombinant (His)

TMPY-02921

Species: Human

Expression System: E. coli

Human Papilloma Virus type 16 (HPV 16) Protein E4 (His & Myc)

TMPH-01831

Species: HPV 16

Expression System: E. coli

ZBTB17 Protein, Human, Recombinant (His)

TMPJ-01097

Species: Human

Expression System: E. coli

Human Papilloma Virus type 11 (HPV 11) Protein E4 (His)

TMPH-01826

Species: HPV 11

Expression System: E. coli

Human Papilloma Virus type 6a (HPV 6a) Protein E4 (His & Myc)

TMPH-01839

Species: HPV 6a

Expression System: E. coli

BCCIP Protein, Human, Recombinant (His & GST)

TMPY-04023

Species: Human

Expression System: Baculovirus-Insect Cells

BCCIP Protein, Human, Recombinant

TMPY-00578

Species: Human

Expression System: Baculovirus-Insect Cells

PSPH Protein, Human, Recombinant

TMPY-02766

Species: Human

Expression System: E. coli

FBXW7 Protein, Human, Recombinant (His)

TMPH-01329

Species: Human

Expression System: in vitro E. coli expression system

p53 Protein, Rat, Recombinant (His)

TMPH-03264

Species: Rat

Expression System: E. coli

p53 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02574

Species: Mouse

Expression System: E. coli

Progranulin Protein, Mouse, Recombinant (His)

TMPY-01435

Species: Mouse

Expression System: HEK293

IGF2/IGF-II Protein, Human, Recombinant

TMPY-00150

Species: Human

Expression System: Yeast

p53 Protein, Human, Recombinant (His & SUMO)

TMPH-01075

Species: Human

Expression System: E. coli

PRKN Protein, Rat, Recombinant (His & Myc)

TMPH-03281

Species: Rat

Expression System: Baculovirus

PRKN Protein, Human, Recombinant (His & Myc)

TMPH-01262

Species: Human

Expression System: Baculovirus

PRKN Protein, Human, Recombinant (His & SUMO)

TMPH-01263

Species: Human

Expression System: E. coli

PRKN Protein, Mouse, Recombinant (GST)

TMPH-02631

Species: Mouse

Expression System: E. coli

Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi)

TMPK-01422

Species: Human

Expression System: HEK293

Peptide Ready HLA-A*02:01&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated

TMPK-01421

Species: Human

Expression System: HEK293

APC-equivalent Peptide Ready HLA-A*02:01&B2M Tetramer Protein, Human, MHC (His)

TMPK-01415

Species: Human

Expression System: HEK293

Peptide Ready HLA-A*03:01&B2M Monomer Protein, Human, MHC (His & Avi)

TMPK-01420

Species: Human

Expression System: HEK293

Peptide Ready HLA-A*24:02&B2M Monomer Protein, Human, MHC (His & Avi)

TMPK-01410

Species: Human

Expression System: HEK293

HLA-A*02:01&B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human, MHC (His & Avi)

TMPK-01554

Species: Human

Expression System: HEK293

HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)

TMPK-01519

Species: Human

Expression System: HEK293

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カタログ番号	製品名
L8100	Cell Cycle Compound Library		677 compounds
	A unique collection of 677 cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);

ライブラリー

Cell Cycle Compound Library

L8100

Compounds: 677